Reactive Oxygen Species - Initiated Autophagy Opposes Aldosterone - Induced 1 Podocyte Injury
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چکیده
Reactive Oxygen Species-Initiated Autophagy Opposes Aldosterone-Induced 1 Podocyte Injury 2 3 Mi Bai , Ruochen Che , Yue Zhang , Yanggang Yuan , Chunhua Zhu , Guixia Ding 4 , Zhanjun Jia , Songming Huang , and Aihua Zhang 1,2 5 6 1 Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, 7 Nanjing, China 8 2 Institute of Pediatrics, Nanjing Medical University, Nanjing, China 9 3 Department of Nephrology, The first affiliated hospital of Nanjing Medical University, 10 Nanjing, China 11 12
منابع مشابه
Reactive oxygen species-initiated autophagy opposes aldosterone-induced podocyte injury.
Evidence has demonstrated that aldosterone (Aldo) is involved in the development and progression of chronic kidney diseases. The purpose of the present study was to investigate the role of autophagy in Aldo-induced podocyte damage and the underlying mechanism. Mouse podocytes were treated with Aldo in the presence or absence of 3-methyladenine and N-acetylcysteine. Cell apoptosis was investigat...
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Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient. Recently autophagy has been regarded as a vital cytoprotective mechanism for keeping podocyte homeostasis. Thus, it is reasonable to utilize this mechanism to attenuate podocyte injury....
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Aldosterone is a steroid hormone secreted from the adrenal cortex, which regulates blood pressure. Higher concentrations of aldosterone can cause several diseases, including hypertension, diabetic nephropathy and chronic kidney disease. Previous reports have demonstrated that aldosterone has a pathogenic role in renal injury via reactive oxygen species (ROS), which involves the regulation of au...
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Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular scle...
متن کاملInduction of antioxidant enzymes in murine podocytes precedes injury by puromycin aminonucleoside.
BACKGROUND An imbalance between the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms has been suggested to play an important role in podocyte injury in nephrotic syndrome. Experimental nephrotic syndrome induced by injection of puromycin aminonucleoside (PAN) into rats is a well-established model of nephrotic syndrome, and can be largely prevented by pretreatment w...
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تاریخ انتشار 2016